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US 4,735,956 AGranted
Certain 1,4-dihydro-2,6-di-lower hydrocarbyl-4-heterocyclic-3,5-pyridine dicarboxylates which are useful as calcium channel blockers
AssigneeMerck & Co., Inc.
InventorsJohn J. Baldwin, Wasyl Halczenko, George D. Hartman, Brian T. Phillips
Life of this patent
Estimating the term…
Abstract
Novel substituted 4-heteroaryl-1,4-dihydropyridine compounds useful as calcium channel blockers, pharmaceutical compositions therof, and methods of treatment are disclosed.
Claims7
A compound of the formula:
- ##STR20## wherein, R.sup.1, is a straight or branched chain, saturated or unsaturated hydrocarbon having up to 8 carbon atoms;
- R, is hydrogen or R.sup.1 ;
- and
- R.sup.2 is a heteroaryl selected from the group consisting of:
- ##STR21## wherein, R.sup.1 is as defined above;
- R.sup.3, which may be the same or different, is hydrogen, alkyl C.sub.1-6, phenyl, or phenyl alkyl C.sub.1-6 ;
- R.sup.4 is alkyl C.sub.1-6, phenyl, or phenyl alkyl C.sub.1-6 ;
- R.sup.5 is R.sup.3, chlorine or bromine;
- or a pharmaceutically acceptable salt thereof.
6 more elements
Dependencies are inferred from the claim text.