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US 4,735,955 AGranted
2-substituted cycloheptoimidazole derivatives and anti-ulcerative agents containing the same
AssigneeKotobuki Seiyaku Co., Ltd.
InventorsTsuyoshi Tomiyama, Akira Tomiyama
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Abstract
Derivatives of 2-substituted-cycloheptoimidazole are disclosed, which are represented by the following formula: ##STR1## wherein R is a hydrogen atom, a lower-alkyl, acetyl, lower-alkylaminoalkyl or ethylenedioxyethyl group. A represents a phenyl, pyridyl, benzimidazolyl, imidazolyl, thiazolyl, thiadiazolyl, oxazolyl or isoxazolyl group; each of which optionally possesses one substituent or more and m is 0 or 1, and n is 1 or 2. These compounds are useful as anti-ulcerative agents.
Claims7
A compound of the formula:
- ##STR70## wherein:
- R is a hydrogen atom, a lower-alkyl, acetyl, loweralkylaminoalkyl or 1-ethylenedioxyethyl group;
- A represents a phenyl, pyridyl, benzimidazolyl, imidazolyl, thiazolyl, pyrazolyl, thiadiazolyl, oxazolyl or isoxazolyl group, each of which is optionally substituted by one or more members selected from the group consisting of an amino, methylamino, dimethylamino, nitro, methoxy, chloro, lower alkyl, methylaminomethyl, methylthio, piperidinomethyl, piperidinocarbonyl, methylenedioxy, diethoxymethyl, guanidino, and phenyl group, said phenyl group being optionally substituted by halogen, lower alkyl or alkoxy group;
- m is 0 or 1, n is 1 or 2, or a
- pharmaceutically acceptable acid addition salt thereof.
2 more elements
Dependencies are inferred from the claim text.