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AssigneeSociete de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
InventorAndre Esanu
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This invention relates to 1,3-dihydro-6-methyl-7-hydroxy-furo-(3,4-c)-pyridine derivatives of the general formula I ##STR1## wherein each of A.sub.1 and A.sub.2 independently represents various hydrocarbon groups and therapeutically acceptable addition salts thereof; to a process for the preparation of the same comprising oxidizing the secondary alcohol .alpha..sup.4, 3-o-isopropylidene-1-methyl-5-(1-hydroxy-1-A.sub.1)-methyl pyridine by any usual technique, reacting the resultant ketone with a compound of the general formula XA.sub.2 wherein X stands for Br or I in the presence of magnesium in diethyl ether at the boil and treating the resultant tertiary alcohol with an acidic agent to provoke breaking of the isopropylidene ring and 3,4-cyclisation; and to pharmaceutical compositions containing these derivatives useful for example in diuresis.
A 1,3-dihydro-6-methyl-7-hydroxy-furo-(3,4-c)-pyridine derivative of the formula I ##STR5## wherein A.sub.1 is methyl and A.sub.2 independently represents a straight chain saturated hydrocarbon group having from 1 to 5 carbon atoms or a straight chain unsaturated hydrocarbon group having from 2-5 carbon atoms, a thienyl or furyl group, a phenyl group or a cyclohexyl group, a phenylalkyl group or a phenylalkenyl group, each of the groups represented by A.sub.1 and A.sub.2 being unsubstituted or being substituted by one or more chlorine or fluorine atoms, trifluoromethyl groups, alkyl groups having from 1 to 5 carbon atoms, alkoxy groups having from 1 to 5 carbon atoms, alkylthio groups having from 1 to 5 carbon atoms, dialkylamino groups in which each alkyl group has from 1 to 5 carbon atoms, dialkylaminoalkoxy groups in which each of the two alkyl groups and the alkoxy group has from 1 to 5 carbon atoms or .alpha.- or .beta.-alkoxy-N-pyrrolidinyl groups in which the alkoxy group has from 1 to 5 carbon atoms;
Dependencies are inferred from the claim text.