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US 4,735,949 AGranted
Disubstituted-7-pyrrolidinonaphthyridine antibacterial agents
AssigneeWarner-Lambert Company
InventorsJohn M. Domagala, Susan E. Prugh, Joseph P. Sanchez, Marjorie S. Solomon
Life of this patent
Estimating the term…
Abstract
Disubstituted 7-pyrrolidinoquinoline- and -naphthyridine-3-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections.
Claims6
A compound of the formula ##STR5## wherein X is N;
- R.sub.1 is hydrogen or alkyl of one to six carbon atoms;
- R.sub.2 is alkyl of one to four carbon atoms, vinyl, haloalkyl or hydroxyalkyl of two to four carbon atoms, or cycloalkyl of three to six carbon atoms;
- n is zero to three;
- R.sub.3 is OR.sub.4 or NR.sub.4 R.sub.5, in which R.sub.4 and R.sub.5 are each independently hydrogen or alkyl of one to six carbon atoms;
- Ar is phenyl or phenyl substituted by alkyl of one to four carbon atoms, halogen, trifluoromethyl, OR.sub.4 or NR.sub.4 R.sub.5, or a pharmaceutically acceptable acid addition or base salt thereof.
2 more elements
Dependencies are inferred from the claim text.