Methyllevallorphanium salts having peripheral opiate antagonistic activity
AssigneeSanofi
InventorsAlberto Bianchetti, Dino Nisato, Luciano Manara, Roberto Sacilotto
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Abstract
Methyllevallorphanium salts having peripheral antagonistic activity of formula ##STR1## wherein Y.sup.n(-) represents the anion a pharmaceutically acceptable acid other than halogen and n represents the number of negative charges of said anion; a process for their preparation by exchange of the halogen ion with the Y.sup.n(-) anion; and pharmaceutical compositions containing them as active ingredients.
Claims14
A methyllevallorphanium salt of formula ##STR4## wherein Y.sup.n(-) represents an anion of a pharmaceutically acceptable acid which is methanesulfonic, ethanesulfonic, p-toluenesulfonic, 2-naphtalenesulfonic, 1,5-naphtalenedisulfonic, sulfuric, sulfuric-monomethylester, phosphoric, ascorbic, malonic, maleic, tartaric, fumaric, malic, phytic, citric, succinic or 4,4-methylene-bis-(3-hydroxy-2-naphtoic) acid;
- and n represents the number of negative charges of said anion;
- said compounds having a ID50a/ID50c ratio of greater than 8.
Methyllevallorphanium hydrogen maleate.
Dependencies are inferred from the claim text.