Spiro-dioxolanes, -dithiolanes and -oxothiolanes, and their use in mental therapy
AssigneeSandoz Ltd.
InventorGeorg Bolliger
Life of this patent
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Abstract
Spiro compounds, comprising a five-membered carbocyclic ring interrupted by two heteroatoms in ring positions 1 and 3 chosen from oxygen and sulfur atoms and in which the carbon atom in ring position 4 is common to a 4 to 8-membered carbocyclic ring interrupted by a nitrogen atom, are useful as pharmaceuticals.
Claims7
A compound of formula I ##STR13## wherein R.sub.1 is hydrogen, (C.sub.1-6)alkyl optionally substituted by 1 to 6 halogen atoms with an atomic number of 9 to 35, (C.sub.3-6)alkenyl or (C.sub.3-6)alkynyl wherein the multiple bond is not adjacent to the nitrogen atom, (C.sub.3-7)cycloalkyl, (C.sub.3-7)cycloalkyl(C.sub.1-2)-alkyl, benzyl, (C.sub.2-5)alkoxycarbonyl, benzoxycarbonyl, (C.sub.2-5)alkanoyl, benzoyl, nicotinoyl, dihydronicotinoyl, N-(C.sub.1-4)alkyl-dihydronicotinoyl,
- R.sub.2 and R.sub.3 independently are hydrogen, (C.sub.1-6)alkyl optionally substituted by 1 to 6 halogen atoms with an atomic number of 9 to 35, (C.sub.3-6)alkenyl, (C.sub.3-6)alkynyl, (C.sub.3-7)cycloalkyl or phenyl, or form together a --(CH.sub.2).sub.p -- chain wherein p is 2, 3, 4 or 5,
- X.sub.1 and X.sub.2 independently are --O-- or --S-- and
- m and n independently are 1, 2, 3 or 4, provided that m+n.ltoreq.6, provided that X.sub.1 and X.sub.2 are not both --O-- when
- (a) R.sub.1 and R.sub.2 are methyl, R.sub.3 is hydrogen and m and n are 1, or
- (b) R.sub.1 is t.-butyl, R.sub.2 and R.sub.3 are both H or both methyl and m and n are 2,
- in free base or pharmaceutically acceptable acid addition or quaternary ammonium salt form.
Dependencies are inferred from the claim text.