Eburnamonine oxime derivatives, salts thereof, and pharmaceutical agents containing the same
AssigneeSanwa Kagaku Kenkyusho Co., Ltd.
InventorsMasatoshi Ban, Yutaka Baba, Kiichi Sawai
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Abstract
There is disclosed novel eburnamonine oxime, its derivatives and salts, process for the manufacture thereof and pharmaceutical agents containing the same. The compounds are represented by the following formula. ##STR1## wherein R is hydrogen, alkyl, alkoxyalkyl, or oxisilanylalkyl group or a group of ##STR2## R.sup.1 and R.sup.2 are same or different and respectively hydrogen, alkyl having 1 to 4 carbon atoms, aryl or aralkyl group, or R.sup.1 represents together with R.sup.2 and the neighboring nitrogen atom a non-substituted or substituted heterocyclic ring, and n is an integer of 2 or 3.
Claims4
An eburnamonine oxime compound of the formula ##STR19## wherein R.sup.1 and R.sup.3 are an alkyl radical having 1 to 4 carbon atoms, respectively, or R.sup.1 is a pyrrolidinyl radical together with R.sup.2 and the neighbouring nitrogen atom.
A pharmaceutical agent which comprises as an effective component an eburnamonine oxime compound of the formula ##STR20## wherein R.sup.1 and R.sup.2 are an alkyl radical having 1 to 4 carbon atoms, respectively, or R.sup.1 is a pyrrolidinyl radical together with R.sup.2 and the neighbouring nitrogen atom,
- in an amount effective for a pharmaceutical function selected from increasing cerebral blood flow and improving cerebral metabolism;
- in addition to a pharmaceutically acceptable carrier.
An eburnamonine oxime derivative and a non-toxic salt thereof selected from the group consisting of (3.alpha.,16.alpha.)-eburnamenin-14(15H)-one O-{2-hydroxy-3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl}-oxime (3.alpha.,16.alpha.)-eburnamenin-14(15H)-one O-{2-[4-(2-methoxyphenyl)-1-piperazinyl]-ethyl}oxime and (3.alpha.,16.alpha.)-eburnamenin-14(15H)-one O-{2-hydroxy-3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl}-oxime.
A pharmaceutical agent which comprises as an effective component, an eburnamonine oxime derivative selected from the group consisting of (3.alpha.,16.alpha.)-eburnamenin-14(15H)-one O-{2-[4-(2-methoxyphenyl)-1-piperazinyl]-ethyl}oxime and (3.alpha.,16.alpha.)-eburnamenin-14(15H)-one O-{2-hydroxy-3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl}-oxime,
- in an amount effective for a pharmaceutical function selected from increasing cerebral blood flow and improving cerebral metabolism;
- in addition to a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.