Malaria vaccine
OwnerManuel E. Patarroyoinventor
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Abstract
A mixture of the synthetic peptide compounds of the formulas: Try-Gly-Gly-Pro-Ala-Asn-Lys-Lys-Asn-Ala-Gly-OH, Formula (I) Asp-Glu-Leu-Glu-Ala-Glu-Thr-Gln-Asn-Val-Tyr-Ala-Ala-NH.sub.2, Formula (II) and Tyr-Ser-Leu-Phe-Gln-Lys-Glu-Lys-Met-Val-Leu-NH.sub.2, Formula (III) and compositions thereof, induces antibodies against the late stages of Plasmodium falciparum malaria and provides protection against infection with this parasite, thus providing a synthetic malaria vaccine for Plasmodium falciparum induced malaria.
Claims19
A compound of the formula Tyr-Gly-Gly-Pro-Ala-Asn-Lys-Lys-Asn-Ala-Gly-OH.
A compound of the formula Asp-Glu-Leu-Glu-Ala-Glu-Thr-Gln-Asn-Val-Tyr-Ala-Ala-NH.sub.2.
A compound of the formula Tyr-Ser-Leu-Phe-Gln-Lys-Glu-Lys-Met-Val-Leu-NH.sub.2.
A compound of the formula Lys-Leu-Tyr-Gln-Ala-Gln-Tyr-Asp-Leu-Ser-Ile-OH.
A compound of the formula Lys-Lys-Phe-Thr-Lys-Asp-Glu-Asn-Lys-Pro-Asp-Glu-OH.
A composition for vaccinating against P. falciparum induced malaria which comprises a mixture of the compounds:
- Tyr-Gly-Gly-Pro-Ala-Asn-Lys-Lys-Asn-Ala-Gly-OH Formula (I)
- and
- Asp-Glu-Leu-Glu-Ala-Glu-Thr-Gln-Asn-Val-Tyr-Ala-Ala-NH.sub.2 Formula (II)
- in a vehicle suitable for parenteral administration.
Dependencies are inferred from the claim text.