US 4,735,793 A · Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes

Abstract

A coordination complex comprising a radionuclide selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt and Re and an isonitrile ligand of the formula: (CNX)R, where X is a lower alkyl group having 1 to 4 carbon atoms, wherein R is selected from the group consisting of COOR.sup.1 and CONR.sup.2 R.sup.3 where R.sup.1 can be H, a pharmaceutically acceptable cation, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, R.sup.2, and R.sup.3 can be H, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, and R.sup.2 and R.sup.3 can be the same or different is disclosed. Kits that can be used to form these complexes are also disclosed.

Claims28

Dependent claims

A coordination complex of a lower alkyl isonitrile ligand of the formula:

CN--X--R,
where X is a lower alkyl group having 1 to 4 carbon atoms, wherein R is selected from the group consisting of COOR.sup.1 and CONR.sup.2 R.sup.3 where R.sup.1 can be H, a pharmaceutically acceptable cation, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, R.sup.2, and R.sup.3 can be H, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, and R.sup.2 and R.sup.3 can be the same or different;
and
a radioactive metal selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt and Re.

1 more element

Dependencies are inferred from the claim text.

Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes

Life of this patent

Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes

Life of this patent

Abstract

Claims28