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US 4,735,792 AGranted
Radioiodinated maleimides and use as agents for radiolabeling antibodies
AssigneeThe United States of America as represented by the United States Department of Energy
InventorPrem C. Srivastava
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Abstract
A radiopharmaceutical for antibody labeling comprising an iodophenyl maleimide that attaches thiol sites of proteins thereby maintaining bioreactivity largely located at the nitrogen sites.
Claims6
A compound comprising a maleimide having a radiohalogenated phenyl at the nitrogen site, said phenyl having a radiohalogen at the paraposition, wherein said radiohalogen is selected from the group bromine-75, bromine-76, bromine-82, iodine-123, iodine-125, iodine-131 and fluorine-18.
Dependencies are inferred from the claim text.