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US 4,734,501 AGranted
N-alkylation of dihydrolysergic acid
AssigneeEli Lilly and Company
InventorGifford P. Marzoni
Life of this patent
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Abstract
The present invention provides a process for N-alkylating dihydrolysergic acid with a substituted benzenesulfonate derivative.
Claims5
A process for preparing a compound of the formula ##STR4## wherein R.sup.1 is C.sub.3 -C.sub.8 alkyl, --CH.sub.2 C.sub.2 --C.sub.4 alkenyl, propargyl, C.sub.3 -C.sub.8 cycloalkyl or C.sub.1 -C.sub.5 alkyl substituted C.sub.3 -C.sub.8 cycloalkyl, comprising treating a compound of the formula ##STR5## with a substituted benzenesulfonate of the formula ##STR6## wherein R.sup.1 is as defined above and R.sup.2 is methyl in the presence of a suitable alkali metal hydroxide base and solvent.
Dependencies are inferred from the claim text.