N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxome thyl]-N-methylglycine S-oxide and the amide thereof
AssigneeAmerican Home Products Corporation
InventorsEckhardt S. Ferdinandi, Michael S. Malamas, Kazimir Sestanj, Surendra N. Sehgal
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Abstract
Disclosed herein are N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]-N-methylgl ycine S-oxide (tolrestat S-oxide) and the amide thereof and methods of their preparation. The S-oxides are new aldose reductase inhibitors useful for the treatment of prevention of diabetic complications.
Claims5
A purified compound of formula (I) ##STR3## wherein R is --OH or --NH.sub.2 and the pharmaceutically acceptable salts thereof wherein R is --OH.
The compound which is [[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl]methylamino]- acetamide S-oxide and the pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.