Method for the treatment of pruritus and composition for the use therein
AssigneeRorer Pharmaceutical Corporation
InventorsRobert L. Procaccini, Kim D. Lamon, Nicholas S. Hagen
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Abstract
A method for the relief of pruritus comprising the administration of an effective antipruritic amount of a N-(trifluoromethylphenyl)anthranilic acid ester to an afflicted patient.
Claims20
A method for the relief of pruritus in a human or other mammal comprising administering to a human or other mammal afflicted therewith a topical composition comprising an effective percutaneous absorption inhibiting amount of aluminum hydroxide and an effective antipruritic amount of a compound of the formula:
- ##STR4## alkyl, hydroxy alkyl, acyloxy alkyl or alkoxy alkyl;
- or a pharmaceutically acceptable salt thereof.
A method for the relief of the itching, redness and inflammation associated with contact dermititis or actinic dermititis comprising the topical administration to the skin of a human or other mammal afflicted therewith, a composition comprising percutaneous absorption inhibiting amount of aluminum hydroxide, and a topically effective amount of a compound of the formula ##STR5## wherein R.sub.1 is hydrogen, acetyl or lower alkyl.
A method for the relief of a chronic or acute epidermal pruritic sensation comprising the topical administration to a human or other mammal's skin in which said pruritic sensation is localized, a composition including about 0.01 to about 1 wt% of aluminum hydroxide and a topically effective amount of etofenamate.
A method for the prevention of sunburn in humans or other mammals comprising the topical administration to the normal, healthy exposed skin thereof of an effective ultraviolet ray absorbing amount of a compound of the formula ##STR6## alkyl, hydroxy alkyl, acyloxy alkyl or alkoxy alkyl;
- or a pharmaceutically acceptable salt thereof.
An anti-pruritic composition comprising an effective anti-pruritic amount of etofenamate in a pharmaceutically acceptable vehicle formulated to inhibit the percutaneous diffusion of said etofenamate and including aluminum hydroxide.
A method for the long-term relief of ultraviolet ray-induced erythema in humans comprising topically administering to a human or other mammal afflicted therewith a composition comprising an effective percutaneous absorption inhibiting amount of aluminum hydroxide and an effective blanching amount of a compound of the formula:
- ##STR7## , alkyl, hydroxy alkyl, acyloxy alkyl or alkoxy alkyl;
- or a pharmaceutically acceptable salt thereof.
A method for the deterrence of skin damage caused by the undue exposure of human skin to the ultraviolet rays of the sun comprising:
- (1) applying topically to exposed human skin showing no visible signs of inflammation or erythema a composition including about one to about 15 wt% of etofenamate and about 0.1 to about 1 wt % of aluminum hydroxide thereby forming on the surface of said skin an effective ultraviolet ray-absorbing film;
- and
- (2) exposing said skin to the ultraviolet rays of the sun.
Dependencies are inferred from the claim text.