Thiopyranodipyrazoles and their use as bronchodilators
AssigneeMerrell Dow Pharmaceuticals Inc.
InventorsMichael E. Le Tourneau, Norton P. Peet
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Abstract
The present invention is directed to a group of compounds which are variously methylated thiopyranodipyrazoles and to the S-oxides and S-dioxides of such compounds. The compounds are useful as bronchodilators and are prepared by the reaction of appropriately 5-substituted thiopyrano[3,4-c]pyrazol-4-(1H)-one with a hydrazine.
Claims4
A compound of the formula ##STR4## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently hydrogen or methyl with R.sub.1 and R.sub.3 being positioned on one of the nitrogens in their respective rings with the other nitrogen then being doubly bonded to the adjacent carbon;
- the dotted lines indicate the presence of two conjugated double bonds with the specific position of the double bonds being determined by the position of the R.sub.1 and R.sub.3 substituents;
- and n is 0, 1 or 2.
A method for alleviating bronchial spasm in mammals which comprises administering to a mammal in need thereof a bronchodilating amount of a compound of the formula ##STR6## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently hydrogen or methyl with R.sub.1 and R.sub.3 being positioned on one of the nitrogens in their respective rings with the other nitrogen then being doubly bonded to the adjacent carbon;
- the dotted lines indicate the presence of two conjugated double bonds with the specific position of the double bonds being determined by the position of the R.sub.1 and R.sub.3 substituents;
- and n is 0, 1 or 2.
Dependencies are inferred from the claim text.