Cycloalkane[1,2-c:4,3-c']dipyrazoles and their use as bronchodilators
AssigneeMerrell Dow Pharmaceuticals Inc.
InventorsMichael E. Le Tourneau, Norton P. Peet
Life of this patent
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Abstract
The present invention is directed to a group of methylated tetrahydro cyclohepta[1,2-c:4,3-c']dipyrazoles and benzo[1,2-c:4,3-c']dipyrazoles useful as bronchodilators. The compounds are prepared by the reaction of an appropriate hydrazine with an appropriate 1,3-diketone or with a compound that is chemically equivalent to a 1,3-diketone.
Claims7
A compound of the formula ##STR4## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently selected from hydrogen or methyl with the proviso that at least one of them must be methyl and with R.sub.1 and R.sub.3 being positioned on one of the nitrogens in their respective rings with the other nitrogen then being doubly bonded to the adjacent carbon;
- the dotted lines indicate the presence of two conjugated double bonds with the specific position of the double bonds being determined by the position of the R.sub.1 or R.sub.3 substituents;
- and Z is --(CH.sub.2)n-- wherein n is 2 or 3.
A method for alleviating bronchial spasm in mammals which comprises administering to a mammal in need thereof a bronchodilating amount of a compound of the formula ##STR6## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently selected from hydrogen or methyl with the proviso that at least one of them must be methyl and with R.sub.1 and R.sub.3 being positioned on one of the nitrogens in their respective rings with the other nitrogen then being doubly bonded to the adjacent carbon;
- the dotted lines indicate the presence of two conugated double bonds with the specific position of the double bonds being determined by the position of the R.sub.1 or R.sub.3 substituents;
- and Z is --(CH.sub.2)n-- wherein n is 2 or 3.
Dependencies are inferred from the claim text.