Aminoethylimidazole and cytoprotective and gastric antisecretory composition containing the same
AssigneeJouveinal S.A.
InventorsGilbert G. Aubard, Jacques Bure, Agnes G. Grouhel, Jean-Louis Junien, Veronique J. Lelievre, Xavier B. Pascaud, Claude P. Roux
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Abstract
Aminoethyl imidazole of formula: ##STR1## in which R.sub.1 is a lower alkyl, R.sub.2 is a phenyl or phenoxy radical, optionally substituted by a halogen atom or a lower alkoxy radical, R.sub.3,R.sub.4 and R.sub.5 are a hydrogen atom or a lower alkyl radical and x, y and z have the value 0 or 1, but the values of y and z cannot be the same, together with their acid addition salts with acids. Cytoprotective medicament.
Claims5
Aminoethyl imidazole of formula:
- ##STR14## wherein R.sub.1 is lower alkyl,
- R.sub.2 is lower alkyl, phenyl or phenoxy, optionally substituted by halogen, lower alkoxy or phenyl,
- R.sub.3, R.sub.4 and R.sub.5, each represent hydrogen,
- x, y and z are 0 or 1 with the proviso that y and z cannot be the same, or a pharmaceutically acceptable addition salt with an acid.
A pharmaceutical composition having a cytoprotective and gastric antisecretory activity, said composition comprises a pharmaceutically acceptable carrier and a therapeutically effective amount of an aminoethyl imidazole of formula:
- ##STR15## wherein R.sub.1 is lower alkyl,
- R.sub.2 is lower alkyl, phenyl or phenoxy, optionally substituted by halogen, lower alkoxy or phenyl,
- R.sub.3, R.sub.4 and R.sub.5, each represent hydrogen,
- x, y and z are 0 or 1 with the proviso that y and z cannot be the same,
- or a pharmaceutically acceptable salt with an acid.
Dependencies are inferred from the claim text.