7-oxabicycloheptane substituted hydroxamic acid prostaglandin analogs

A compound having the structure ##STR81## including all stereoisomers thereof, wherein A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --;

• n is 1 to 5;
• R is CO.sub.2 H, CO.sub.2 alkyl, CO.sub.2 alkali metal, CO.sub.2 polyhydroxyamine salt, --CH.sub.2 OH, ##STR82## wherein R.sup.4 and R.sup.5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl at least one of R.sup.4 and R.sup.5 being other than hydroxy and lower alkoxy;
• q is 1 to 12;
• R.sup.1 is H or OH;
• R.sup.2 is OH or H provided that one of R.sup.1 and R.sup.2 is OH and the other is H;
• and R.sup.3 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, arylalkoxy, aryloxy, alkylamino, arylamino, arylalkylamino, lower alkyl-S-, aryl-S-, arylalkyl-S-, ##STR83## (wherein n' is 0, 1 or 2), alkylaminoalkyl, arylaminoalkyl, arylalkylaminoalkyl, alkoxyalkyl, aryloxyalkyl or arylalkoxyalkyl, wherein lower alkyl or alkyl alone or as part of another group contains 1 to 12 carbons and is unsubstituted or is substituted with halo, CF.sub.3, alkoxy, aryl, alkyl-aryl, haloaryl, cycloalkyl, alkylcycloalkyl, hydroxy, alkylamino, alkanoylamino, arylcarbonylamino, nitro, cyano, thiol or alkylthio;
• cycloalkyl alone or as part of another group is a saturated cyclic hydrocarbon group containing 3 to 12 carbons, which is unsubstituted or substituted with 1 or 2 halogens, 1 or 2 lower alkyl groups, 1 or 2 lower alkoxy groups, 1 or 2 hydroxy groups, 1 or 2 alkylamino groups, 1 or 2 alkanoylamino groups, 1 or 2 arylocarbonyl amino groups, 1 or 2 amino groups, 1 or 2 nitro groups, 1 or 2 cyano groups, 1 or 2 thiol groups and/or 1 or 2 alkylthio groups;
• and
• aryl alone or as part of another group is a monocyclic or bicyclic aromatic group containing from 6 to 10 carbons in the ring portion and which is unsubstituted or is substituted with 1 or 2 lower alkyl groups, 1 or 2 halogens, 1 or 2 lower alkoxy groups, 1 or 2 hydroxy groups, 1 or 2 alkylamino groups, 1 or 2 alkanoylamino groups, 1 or 2 arylcarbonylamino groups, 1 or 2 amino groups, 1 or 2 nitro groups, 1 or 2 cyano groups, 1 or 2 thiol groups and/or 1 or 2 alkylthio groups.