Pyrrolizidine compounds, salts thereof, process for the preparation of same and pharmaceutical agents comprising same

A compound and a salt thereof as claimed in vlaim 1, wherein said compound is 10-(7a-pyrrolizidinylmethyl)-1-trimethylsilyl-phenothiazine.

A process for the preparation of a pyrrolizidine compound represented by the formula ##STR20## wherein R.sup.4 is hydrogen, halogen, alkyl group or alkoxy group and m is an integer of 0 to 5.

• and a salt thereof, which comprises a step of reacting in the presence of a base a compound represented by the formula ##STR21## wherein R.sup.4 has the meaning as referred to and X is halogen, with a compound represented by the formula ##STR22## wherein X and m have the meanings as referred to, subjecting to a ring closing reaction the resulting compound represented by the formula ##STR23## wherein R.sup.4, X and m have the meanings as referred to, and if necessary, converting the resulting ring-closed free base compound into the salt.

A pharmacological composition for the treatment of gastric ulcer, which comprises an anti-gastric ulcer effective amount of a pyrrolizidine compound of the formula ##STR24## wherein R is a radical of ##STR25## R.sup.1 is hydrogen, halogen, alkyl group, alkoxy group, alkanoyl group, trifluoromethyl radical, trimethylsilyl radical or ##STR26## R.sup.2 and R.sup.3 are same or different and are hydrogen or alkyl group, respectively, R.sup.4 is hydrogen, halogen, alkyl group or alkoxy group and m is an integer of 0 to 5, of a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.