Crystalline cephalosporin antibiotic salts and solvates
AssigneeEli Lilly and Company
InventorAllen S. Katner, deceased
Life of this patent
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Abstract
The crystalline sulfate dihydrate, dimethylacetamide hydrate and dimethylformamide hydrate solvates of the antibiotic syn-7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-(3-methyl-3H-imi dazolo[4,5-c]pyridinium-5-ylmethyl)-3-cephem-4-carboxylate are provided.
Claims6
Crystalline syn-7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-(3-methyl-3H-imi dazolo-[4,5-c]pyridinium-5-ylmethyl)-3-cephem-4-carboxylate dimethylacetamide hydrate exhibiting essentially the following X-ray diffraction pattern:
- ______________________________________ Relative Spacing, d(A) Intensities, I/I.sub.1 ______________________________________ 14.03 0.45 9.88 0.85 8.71 0.20 7.00 1.00 6.39 0.15 6.24 0.20 5.56 0.20 5.39 0.80 5.05 0.20 4.89 0.25 4.65 0.35 4.42 0.35 4.20 0.25 4.00 0.35 3.90 0.05 3.70 0.20 3.56 0.40 3.47 0.40 3.34 0.20 3.20 0.10 3.09 0.25 2.97 0.10 2.75 0.05 2.71 0.05. ______________________________________
Crystalline syn- 7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-(3-methyl-3H-imidazo lo[4,5-c]-pyridinium-5-ylmethyl)-3-cephem-4-carboxylate dimethyl-formamide hydrate exhibiting essentially the following X-ray diffraction pattern:
- ______________________________________ Relative Spacing, d(A) Intensities, I/I.sub.1 ______________________________________ 13.92 0.45 9.88 0.91 8.76 0.27 7.66 0.18 7.03 1.00 6.46 0.09 6.15 0.18 5.56 0.45 5.32 0.55 5.08 0.55 4.86 0.36 4.61 0.36 4.42 0.36 4.21 0.18 4.00 0.36 3.79 0.09 b 3.69 0.18 3.49 0.36 b 3.33 0.09 3.16 0.09 3.10 0.27 2.92 0.18. ______________________________________
Crystalline syn- 7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-(3-methyl-3H-imidazo lo [4,5-c]-pyridinium-5-ylmethyl)-3-cephem-4-carboxylate sulfate dihydrate exhibiting essentially the following X-ray diffraction pattern:
- ______________________________________ Relative Spacing, d(A) Intensities, I/I.sub.1 ______________________________________ 11.63 0.82 8.76 0.18 7.60 0.06 6.78 0.94 5.95 0.06 5.44 0.12 5.14 0.29 4.45 1.00 4.18 0.65 3.86 0.18 3.72 1.00 3.57 0.24 3.39 0.59 3.27 0.47 3.15 0.06 3.00 0.06 b 2.74 0.06 b 2.62 0.06 2.56 0.06 2.44 0.06 2.13 0.06 2.05 0.06. ______________________________________
Dependencies are inferred from the claim text.