3-pyridylmethylnaphthyl derivatives and composition containing them useful to inhibit thromboxane synthetase

A compound of the formula I ##STR14## in which:

• R.sup.1 denotes hydrogen or, in the 2-, 4-, 5- or 6- position, halogen, a straight chain or branched alkyl radical having 1-6 carbon atoms, a cycloalkyl radical having 3-7 carbon atoms, a phenyl C.sub.1 -C.sub.2 -alkyl radical or a phenyl radical, each of which can be substituted 1-3 times in the phenyl nucleus by halogen, alkyl and/or alkoxy, each having 1-6 carbon atoms, or denotes a hydroxyl radical or an alkoxy radical having 1-6 carbon atoms,
• R.sup.2 denotes a hydroxyl radical, halogen, an alkoxy radical having 1-6 carbon atoms, or a phenoxy radical which can be substituted 1-3 times in the phenyl nucleus by halogen, trifluoromethyl, alkyl and/or alkoxy, each having 1-6 carbon atoms,
• R.sup.3 denotes hydrogen, a cycloalkyl radical having 3-7 carbon atoms, a straight-chain or branched alkyl radical having 1-8 carbon atoms, a straight-chain or branched unsaturated aliphatic hydrocarbon radical having up to 8 carbon atoms and up to 3 double or triple bonds, a phenyl radical which can be substituted 1-3 times in the phenyl nucleus by halogen, trifluoromethyl, hydroxyl, alkyl and/or alkoxy, each having 1-6 carbon atoms, or denotes a 2-, 3- or 4-pyridyl radical which can be substituted in the 4- or 5- position by C.sub.1 - C.sub.4 -alkyl,
• Y denotes a radical of the formula CO.sub.2 R.sup.5, ##STR15## or CH.sub.2 OH, R.sup.5 denoting hydrogen, a straight chain or branched alkyl radical having up to 8 carbon atoms, a straight-chain or branched unsaturated aliphatic hydrocarbon radical having up to 6 carbon atoms, a cycloaliphatic hydrocarbon radical having 3 to 7 carbon atoms, an araliphatic hydrocarbon radical having 7 to 10 carbon atoms, or a physiologically tolerated metal ion, NH.sub.4 ion or an ammonium ion which is derived from a primary, secondary or tertiary amine, or a tetraalkylammonium ion,
• R.sup.6 denoting hydrogen, a straight chain or branched alkyl radical having 1-6 carbon atoms, a cycloaliphatic hydrocarbon radical having 3-7 carbon atoms, an araliphatic hydrocarbon radical which has 7-10 carbon atoms and can be substituted 1-3 times in the aryl nucleus by halogen, trifluoromethyl, alkyl and/or alkoxy, each having 1-6 carbon atoms, or denoting a phenyl radical which can be substituted 1-3 times in the phenyl nucleus by halogen, trifluoromethyl, alkyl and/or alkoxy, each having 1-6 carbon atoms,
• R.sup.7 denoting hydrogen, a straight chain or branched alkyl radical having 1-6 carbon atoms, or
• R.sup.6 and R.sup.7 together denoting a --(CH.sub.2).sub.n --group with n= 3-6, or a --(CH.sub.2).sub.p --Z--(CH.sub.2).sub.p -- group with p=2 or 3,
• Z being oxygen or N--R.sup.8,
• R.sup.8 denoting hydrogen or a straight-chain or branched alkyl radical having 1-6 carbon atoms,
• or a physiologically tolerated acid addition salt thereof, with the exception of the compounds of the formula 1 in which, when Y denotes the radicals --CONH.sub.2 or COOR.sup.5, with R.sup.5 denoting hydrogen or C.sub.1 -C.sub.6 -alkyl, R.sup.1 and R.sup.3 represent hydrogen.