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US 4,734,405 AGranted
Combination product
AssigneeBASF SE
InventorHorst Koenig
Life of this patent
Estimating the term…
Abstract
A combination of acetylsalicylic acid and pyridazinone derivatives can be used for the treatment of thromboembolic disorders.
Claims3
An orally administrable pharmaceutical composition for treating and preventing disorders caused by platelet aggregation which comprises acetylsalicylic acid and a pyridazinone derivative of the formula I ##STR4## where R.sup.1 is hydrogen or methyl, R.sup.2 is hydrogen or, together with R.sup.1, forms methylene or ethylene, R.sup.3 is
- (a) a group of the formula ##STR5## where the dashed line may be an additional bond and, where relevant, R.sup.7 is hydrogen or C.sub.1 -C.sub.4 -acyl, or
- (b) a group of the formula ##STR6## where R.sup.8 is hydrogen or C.sub.1 -C.sub.4 -acyl, or (c) 1,3-tetrahydroisoquinolin-2-yl, R.sup.4 is hydrogen or, together with R.sup.3, forms a direct bond or methylene, R.sup.5 is hydrogen or methyl, R.sup.6 is hydrogen or halogen and n is 0 or 1, acetylsalicylic acid being present in an amount of 30-600 parts by weight and the compound I in an amount of 5-50 parts by weight.
Dependencies are inferred from the claim text.