Anti-curare agents
AssigneeResearch Corporation
InventorsIraj Lalezari, Francis F. Foldes
Life of this patent
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Abstract
This invention relates to a method for antagonizing induced the neuromuscular blocking effects of certain therapeutic agents and pathological disorders in mammals, which comprises administering to said mammal an antagonizing-effective amount of a compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, cycloalkyl, cycloalkyl-lower alkyl or hydroxyalkyl, or, when taken together, form a heterocyclic ring with the nitrogen to which they are attached, with the proviso that both are not hydrogen; R.sub.3 is hydrogen or alkyl; and R.sub.4 is hydrogen, alkyl, alkenyl, alkynyl, halogen or acyl; or a salt thereof with acids.
Claims28
A method for antagonizing neuromuscular blocking effects induced by therapeutic agents and physiological disorders in mammals, which comprises administering to said mammal an antagonizing-effective amount of a compound of the formula:
- ##STR5## wherein R.sub.2 and R.sub.2 are each hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl, aralkyl, cycloalkyl, cycloalkyl-lower alkyl or hydroxyalkyl, with the proviso that both are not hydrogen;
- R.sub.3 is hydrogen or lower alkyl;
- and
- R.sub.4 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, halogen or acyl;
- wherein the alkyl groups in alkyl per se, aralkyl, cycloalkyl-lower alkyl and hydroxyalkyl contain from 1 to 6 carbon atoms;
- the cycloalkyl groups in cycloalkyl per se and cycloalkyl-lower alkyl contain from 4 to 8 carbon atoms;
- the alkenyl and alkynyl groups contain from 2 to 6 carbon atoms;
- the acyl group contains from 1 to 6 carbon atoms;
- and the aryl groups in aryl per se and aralkyl contain from 6 to 10 carbon atoms;
- or a salt thereof with acid.
A therapeutic composition for the antagonism of neuromuscular block which comprises a compound of the formula:
- ##STR6## at a unit dosage level of from about 0.1 to about 6.0 mg/kg. wherein R.sub.1 and R.sub.2 are each hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl, aralkyl, cycloalkyl, cycloalkyl-lower alkyl or hydroxyalkyl, with the proviso that both are not hydrogen;
- R.sub.3 is hydrogen or alkyl;
- and
- R.sub.4 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, or halogen or acyl;
- wherein the alkyl groups in alkyl per se, aralkyl, cycloalkyl-lower alkyl and hydroxyalkyl contain from 1 to 6 carbon atoms;
- the cycloalkyl groups in cycloalkyl per se and cycloalkyl-lower alkyl contain from 4 to 8 carbon atoms;
- the alkenyl and alkynyl groups contain from 2 to 6 carbon atoms;
- the acyl group contains from 1-6 carbon atoms and the aryl groups in aryl per se and aralkyl contain from 6 to 10 carbon atoms;
- or a salt thereof with acid.
Dependencies are inferred from the claim text.