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US 4,733,009 AGranted
Method for separating glycine and L-serine from a solution containing same
AssigneeMitsui Toatsu Chemicals, Inc.
InventorsShoichiro Miyahara, Toshio Matsumoto, Tooru Miyahara, Akio Sakaguchi, Kazunari Nitta
Life of this patent
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Abstract
Disclosed is a method for separating lycine and L-serine from a solution containing both of them in the dissolved state and, in particular, a reaction solution obtained from a fermentation or enzymic conversion process for the preparation of L-serine by using glycine as the raw material. This method is based on a chromatographic technique utilizing the differential affinity of L-serine and glycine for a strongly acidic ion exchange resin.
Claims9
A method for separating glycine and L-serine from a solution thereof which comprises:
- (a) passing a solution containing both glycine and L-serine in the dissolved state through a column of a strongly acidic ion exchange resin having an effective size of 0.15 to 0.40 mm and a uniformity coefficient of not greater than 1.7 at a linear velocity of not greater than 2 meters per hour, followed by passing water through the column at a linear velocity of not greater than 2 meters per hour to obtain an effluent fraction containing a substantial portion of said L-serine charged as an effluent, while retaining the glycine within the column, and then
- (b) bringing an alkaline solution into contact with the column to obtain an eluate containing substantially all of said glycine.
Dependencies are inferred from the claim text.