Octahydronaphthalene derivatives and their preparation
AssigneeSankyo Company, Limited
InventorsJunya Ide, Shigeki Muramatsu, Yoshio Tsujita, Msao Kuroda
Life of this patent
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Abstract
Compounds of formula (I): ##STR1## [wherein X represents a hydrogen atom or a 2-methylbutyryl group, Y represents a hydrogen atom or a methyl group and R.sup.1 and R.sup.2 are the same or different and each represents an oxygen atom or a group of formula .dbd.N--OR.sup.3 (wherein R.sup.3 represents a hydrogen atom or an alkyl group)], the free hydroxy-carboxylic acids corresponding thereto and salts and esters of said acids may be prepared by oxidizing and, if necessary, oximating a corresponding ML-236A, ML-236B, MB-530A or MB-530B compound, and these compounds have valuable antihypercholesteraemic activity.
Claims14
A compound of the formula (II):
- ##STR17## wherein X represents a hydrogen atom or a 2-methylbutyryl group;
- Y represents a hydrogen atom or a methyl group;
- R.sup.1 and R.sup.2 are the same or different and each represents an oxygen atom or a group of formula .dbd.N--OR.sup.3 wherein R.sup.3 represents a hydrogen atom or an alkyl grouo and with the proviso that at least one of R.sup.1 and R.sup.2 is .dbd.N--OR.sup.3);
- or a pharmaceutically acceptable salt or ester thereof.
Dependencies are inferred from the claim text.