Optically-active di-[3-chloro-2-oxy-propyltrimethylammonium]-tartrate
AssigneeLonza Ltd.
InventorsLeander Tenud, Jacques Gosteli
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Abstract
Process for the production of optically-active di-[3-chloro-2-oxy-propyltrimethylammonium]-tartrate. Racemic 3-chloro-2-oxy-propyltrimethylammonium-chloride is converted by racemate resolution with optically-active tartaric acid into the optically-active di-[3-chloro-2-oxy-propyltrimethylammonium]-tartrate. Such optically-active tartrate compound is dissociated in tartaric acid to optically-active 3-chloro-2-oxy-propyltrimethylammonium-chloride and the latter is converted with inorganic cyanides. From the product, the production of optically-active carnitine nitrile chloride can be achieved.
Claims8
Process for producing optically-active carnitine nitrile chloride from optically-active di-(3-chloro-2-oxy-propyltrimethylammonium)-tartrate comprising (a) dissociating di-(3-chloro-2-oxypropylmethylammonium)-tartrate using tartaric acid at a temperature and a pH which are effective to achieve said dissociation, whereby optically-active 3-chloro-2-oxy-propyltrimethylammonium is obtained, (b) converting the latter with a strong base into optically-active glycidyltrimethylammonium chloride at a temperature and a pH which are effective to achieve said conversion, and (c) reacting the chloride with acetone cyanohydrin or prussic acid at a temperature and a pH which are effective to achieve said reaction, whereby the optically-active carnitine nitrile chloride results.
Dependencies are inferred from the claim text.