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US 4,732,980 AGranted
Intermediates for 3-amino-1,2,5-thiadiazole-1-oxides
AssigneeSmith Kline & French Laboratories Limited
InventorsThomas H. Brown, Peter Blurton
Life of this patent
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Abstract
This invention relates to intermediates of Mannich-alkynyl aminothiadiazole oxides having histamine H.sub.2 -antagonist activity. A particular final product of this invention is 3-amino-4-[7-piperidinohept-5-ynylamino]-1,2,5-thiadiazole-1-oxide.
Claims1
A compound of the formula (V):
- ##STR9## wherein:
- R.sup.1 and R.sup.2 are independently hydrogen or C.sub.1-6 alkyl, or R.sup.1 and R.sup.2 together represent --(CH.sub.2).sub.q --wherein q is 4 to 7, to form together with the nitrogen atom to which they are attached, a 5-8 membered saturated ring, optionally substituted by C.sub.1-6 alkyl;
- X is --CH.sub.2 --or sulphur;
- n is 2 or 3, or if X is --CH.sub.2 --n can also be 1;
- is 1 or 2;
- and
- L is halogen, phenylthio, C.sub.1-6 alkoxy, or C.sub.1-6 alkylthio.
4 more elements
Dependencies are inferred from the claim text.