Novel substituted naphthyloxymethyl quinoline derivatives as anti-inflammatory and antiallergy agents
AssigneeAmerican Home Products Corporation
InventorsAnthony F. Kreft, Kenneth L. Kees, John H. Musser, James J. Bicksler, Winifred P. Howse
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Abstract
There are disclosed compounds having the formula ##STR1## wherein X is CR or N when n=1; or X is O, S, NR or CR when n=0; R is hydrogen or lower alkyl; Y is --CH.sub.2 --, --S--, --O-- or ##STR2## and A is ##STR3## Z is CH or N; R.sup.1 is halo or trifluoromethyl; R.sup.2 is hydrogen or halo; R.sup.3 is hydrogen or halo; with the proviso that when A is naphthyl, Y is --O-- and n=0, X is other than S; and their use in the treatment of inflammatory conditions and in the treatment of leukotriene-medicated naso-bronchial obstructive passageway conditions.
Claims5
A compound having the formula ##STR9## wherein R is hydrogen or lower alkyl;
- Y is --CH.sub.2 --, --S--, --O-- or ##STR10## and A is ##STR11## R.sup.2 is hydrogen or halo;
- and R.sup.3 is hydrogen or halo.
Dependencies are inferred from the claim text.