Carbapenem antibiotics
AssigneeBristol-Myers Company
InventorChoung U. Kim
Life of this patent
Estimating the term…
Abstract
Disclosed are novel carbapenem derivatives characterized by a 2-substituent of the formula ##STR1## in which A represents a C.sub.1 -C.sub.6 straight or branched chain alkylene group; R.sup.5 represents an optionally substituted aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aryl, araliphatic, heteroaryl, heteroaraliphatic, heterocyclyl or heterocyclyl-aliphatic radical and ##STR2## represents a nitrogen-containing aromatic heterocycle attached to the alkylene group A at a ring carbon atom and quaternized by substituent R.sup.5. Such derivatives are useful as potent antibacterial agents.
Claims10
A compound having the formula ##STR411## wherein A is C.sub.1 -C.sub.6 straight or branched chain alkylene;
- R.sup.2 is hydrogen, an anionic charge or a conventional readily removable carboxyl protecting group, providing that when R.sup.2 is hydrogen or a protecting group, there is also present a counter ion;
- and ##STR412## represents a radical of the formula ##STR413## wherein R.sup.5 is C.sub.1 -C.sub.6 alkyl and wherein available ring carbon atoms are optionally substituted by 1-3 substituents independently selected from C.sub.1 -C.sub.4 alkyl;
- ##STR414## wherein R.sup.5 is C.sub.1 -C.sub.6 alkyl and wherein available ring carbon atoms are optionally substituted by 1 or 2 substituents independently selected from C.sub.1 --C.sub.4 alkyl;
- or ##STR415## wherein R.sup.5 is C.sub.1 -C.sub.6 alkyl and wherein an available ring carbon atom is optionally substituted by C.sub.1 -C.sub.4 alkyl;
- or a pharmaceutically acceptable salt thereof.
A compound having the formula ##STR419## wherein A is C.sub.1 -C.sub.6 straight or branched chain alkylene;
- R.sup.2 is hydrogen, an anionic charge or a conventional readily removable carboxyl protecting group, providing that when R.sup.2 is hydrogen or a protecting group, there is also present a counter ion;
- and ##STR420## represents a radical of the formula ##STR421## wherein R.sup.5 is C.sub.1 -C.sub.6 alkyl and wherein available ring carbon atoms are optionally substituted by 1-3 substituents independently selected from C.sub.1 -C.sub.4 alkyl;
- ##STR422## wherein R.sup.5 is C.sub.1 -C.sub.6 alkyl and wherein available ring carbon atoms are optionally substituted by 1 or 2 substituents independently selected from C.sub.1 -C.sub.4 alkyl;
- or ##STR423## wherein R.sup.5 is C.sub.1 -C.sub.6 alkyl and wherein an available ring carbon atom is optionally substituted by C.sub.1 -C.sub.4 alkyl;
- or a pharmaceutically acceptable salt thereof.
A compound of the formula ##STR427## wherein R.sup.2 is hydrogen, an anionic charge or a conventional readily removable carboxyl protecting group, providing that when R.sup.2 is hydrogen or a protecting group, there is also present a counter ion;
- or a pharmaceutically acceptable salt thereof.
A compound of the formula ##STR428## wherein R.sup.2 is hydrogen, an anionic charge or a conventional readily removable carboxyl protecting group, providing that when R.sup.2 is hydrogen or a protecting group, there is also present a counter ion;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.