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US 4,732,900 AGranted
1,2,4-triazolo-carbamates
AssigneeBoehringer Ingelheim GmbH
InventorsKarl-Heinz Weber, Dieter Hinzen, Franz-Josef Kuhn, Erich Lehr, Wilhelm Frolke, Wolfgang Troger, Helmut Ensinger, Gerhard Walther, Albrecht Harreus
Life of this patent
Estimating the term…
Abstract
New 1,2,4-triazolo-carbamates of general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the meanings given in the specification, are acetylcholinesterase inhibitors and may be used as drugs for the treatment of senile dementia.
Claims10
A 1,2,4-triazolo-carbamate of the formula ##STR58## wherein
- R.sup.1 is hydrogen, a straight-chained or branched alkyl group with 1 to 8 carbon atoms, a 3 to 6-membered carbocyclic ring, a benzyl or phenethyl group;
- R.sup.2 is a phenyl or pyridinyl group which may be mono- or disubstituted by halogen, methyl, methoxy or trifluoromethyl;
- R.sup.3 and R.sup.4, which may be identical or different, are each hydrogen, a straight-chained or branched alkyl group with 1 to 6 carbon atoms, a cycloalkyl group with 3 to 6 carbon atoms, a phenyl pyridine or pyrazine group optionally substituted by halogen, methoxy or trifluoromethyl or by a straight-chained or branched alkyl group with 1 to 6 carbon atoms;
- or, R.sup.3 and R.sup.4 together with the nitrogen atom to which they are attached form a (ILLEGIBLE) optionally substituted by one or more straight-chained or branched alkyl groups with 1 to 4 carbon atoms, or a physiologically acceptable acid addition salts thereof.
1 more element
Dependencies are inferred from the claim text.