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US 4,732,895 AGranted
.alpha.-[5-methyl-2-(pyridinyl)-1H-imidazol-4-yl]substituted-1-p iperazineethanols useful for treating hypertension
AssigneeAmerican Cyanamid Company
InventorsCorris M. Hofmann, Howard Newman, Andrew S. Tomcufcik
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Abstract
This disclosure describes novel substituted .alpha.-[5-methyl-2-pyridyl-1H-imidazol-4-yl]-1-piperazineethanols which possess hypotensive activity.
Claims23
A compound selected from the group consisting of those of the formula:
- ##STR5## wherein R.sub.1 is phenyl, monosubtituted phenyl [wherein the substituents are fluoro, chloro, bromo, trifluoromethyl, alkyl (C.sub.1 -C.sub.3) or alkoxy (C.sub.1 -C.sub.3)], 2-thiazxolyl, 2-pyrimidinyl or 2-chlorodibenzo [b,f][1,4]oxazepin-11-yl, R.sub.2 is hydrogen or alkyl (C.sub.1 -C.sub.3) and R.sub.3 is hydrogen, phenyl or alkyl (C.sub.1 -C.sub.3);
- and the pharmacologically acceptable acid-addition salts thereof.
A compound of the formula:
- ##STR6## wherein R.sub.1 is phenyl, monosubstituted phenyl [wherein the substituents are fluoro, chloro, bromo, trifluoromethyl, alkyl (C.sub.1 -C.sub.3) or alkoxy (C.sub.1 -C.sub.3)],2-thiazolyl, 2-pyrimidinyl or 2-chlorodibenzo [b,f][1,4] oxazepin-11-yl and R.sub.2 is hydrogen or alkyl (C.sub.1 -C.sub.3).
Dependencies are inferred from the claim text.