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US 4,732,859 AGranted
Method for conferring bacteriophage resistance to bacteria
AssigneeEli Lilly and Company
InventorsCharles L. Hershberger, Paul R. Rosteck, Jr.
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Abstract
A novel method for protecting a bacterium from a naturally occurring bacteriophage and the cloning vectors and transformants for carrying out the aforementioned method are disclosed.
Claims15
A recombinant DNA cloning vector comprising
- (1) a DNA segment that confers a restriction and cognate modification activity to a bacterium,
- (2) a replicon that is functional in said bacterium and,
- (3) a gene that expresses a functional polypeptide in said bacterium
- subject to the limitation that (1) said modification activity is expressed in said bacterium prior to said restriction activity and (2) that said gene that expresses a functional polypeptide is neither a gene that confers antibiotic resistance to said bacterium nor said DNA segment that confers restriction or cognate modification activity to the bacterium.
1 more element
Dependencies are inferred from the claim text.