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US 4,732,853 AGranted
Method of making chiral epoxy alcohols
AssigneePresident and Fellows of Harvard College
InventorsGeorge M. Whitesides, Wolfgang Ladner
Life of this patent
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Abstract
Racemic carboxylic acid esters of epoxy alcohols are enantio selectively hydrolyzed with hydrolytic enzymes to provide chiral epoxy alcohol and chiral unhydrolyzed ester.
Claims11
The method of making chiral epoxy alcohols and esters which comprises providing a racemic carboxylic acid ester of an epoxy alcohol, bringing said ester into contact with water and a hydrolytic enzyme to hydrolyze said ester to the extent of about 5% to about 95%, and separating the resultant free alcohol from unhydrolyzed ester.
Dependencies are inferred from the claim text.