Preparation with collagenolytic activity having high activity and pharmaceutical compositions containing it

A composition comprising:

• a collagenase which specifically recognizes a peptide sequence X-glycyl-L-prolyl in collagen in an amount effective to treat pathologies manifested by an uncontrolled alteration of collagen-rich structures in man or animal, in which X is a natural amino acid residue linked to the N-terminal end of the glycyl residue, said collagenase cutting said sequence specifically at the level of the X-glycyl linkage to degrade collagen into fragments and besides being inhibited at least partly by myosine;
• an effective amount of a neutral protease which can degrade further said collagen fragments;
• and
• an effective amount of an endonuclease which can contribute to the destruction of DNA released as pus by infected cells;
• the proportions of said protease and said endonuclease with respect to 0.350 .mu.kat of said collagenase not exceeding 200 caseinolytic units for said protease and 500 nucleasic units for said endonuclease.