Preparation of optically-active di-(3-chloro-2-oxy-propyltrimethylammonium)-tartrate
AssigneeLonza Ltd.
InventorsLeander Tenud, Jacques Gosteli
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Abstract
Process for the production of optically-active di-[3-chloro-2-oxy-propyltrimethylammonium]-tartrate. Racemic 3-chloro-2-oxy-propyltrimethylammonium-chloride is converted by racemate resolution with optically-active tartaric acid into the optically-active di-[3-chloro-2-oxy-propyltrimethylammonium]-tartrate. Such optically-active tartrate compound is dissociated in tartaric acid and optically-active 3-chloro-2-oxy-propyltrimethylammonium-chloride and the latter is converted with inorganic cyanides. From the product, the production of optically-active carnitine nitrile chloride can be achieved.
Claims6
Process for the production of di-[(-)-3-chloro-2-oxy-propyltrimethylammonium]-L-(+)-tartrate comprising converting racemic 3-chloro-2-oxypropyltrimethylammonium-chloride by racemate resolution with L-(+)-tartaric acid in the presence of a trialkyl amine into the di-[(-)-3-chloro-2-oxy-propyltrimethylammonium]-L-(+)-tartrate.
Process for the production of di-[(-)-3-chloro-2-oxy-propyltrimethylammonium]-L-(+)-tartrate comprising converting racemic 3-chloro-2-oxy-propyltrimethylammonium chloride by racemate resolution with the silver salt of L-(+)-tartaric acid into the di-[(-)-3-chloro-2-oxypropyltrimethylammonium]-L-(+)-tartrate.
Process for the production of di-[(-)-3-chloro-2-oxy-propyltrimethylammonium]-L-(+)-tartrate comprising reacting L-(+)-tartaric acid, dissolved in water or suspended in an alcohol, with trimethyl amine and subsequently converting the reaction product thereof at a temperature of 10.degree. to 35.degree. C. with epichlorohydrin into the di-[(-)-3-chloro-2-oxy-propyltrimethylammonium]-L-(+)-tartate.
Dependencies are inferred from the claim text.