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US 4,731,477 AGranted
Process for the ring cleavage of 2-isopropyl-5,5-dimethylthiazolidines substituted in the 4-position
AssigneeDegussa AG
InventorsHans-Guenter Koban, Edgar Koberstein, Juergen Martens
Life of this patent
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Abstract
A process for the ring cleavage of 2-isopropyl-5,5-dimethylthiazolidines in aqueous acid medium at elevated temperature. Whenever the five ring in the 4-position is substituted by a carboxyl group, penicillamine is the resultant product.
Claims7
A process for the ring cleavage of a 2-isopropyl-5,5-dimethylthiazolidine compound substituted in the 4-position or mineral acid salts thereof comprising hydrolyzing in an aqueous acid medium, a compound represented by structural formula:
- ##STR2## or a mineral acid salt therof, wherein A represents COOH, or an N-mono- or N-disubstituted carbonamide or thiocarboxylic acid amide group wherein the substituent is lower alkyl with 1 to 6 carbon atoms or phenyl,
- at a temperature from 80.degree. to 220.degree. C. under autogenous pressure in an autoclave.
Dependencies are inferred from the claim text.