(5,6-dichloro-3-oxo-9A-propyl-2,3,9,9A-tetrahydrofluoren-7-yl)alkanoic acids and alkanimidamides
AssigneeMerck & Co., Inc.
InventorsAdolph M. Pietruszkiewicz, Otto W. Woltersdorf, Jr., Edward J. Cragoe, Jr.
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Abstract
The invention relates to novel [(5,6-dichloro-3-oxo-9a-propyl-2,3,9,9a-tetrahydrofluoren-7-yl)]alkanoic acids and alkanimidamides, their derivatives and their salts. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections, various brain concussions and elevated intracranial pressure.
Claims10
A compound of the formula:
- ##STR9## wherein:
- R is --COOH;
- R.sup.1 is lower alkyl, branched or unbranched, containing from 1 to 5 carbon atoms, phenyl, p-fluorophenyl, o-fluorophenyl, p-chlorophenyl, benzyl, cycloalkyl containing from 3 to 6 nuclear carbon atoms, or cycloalkyl-lower alkyl containing from 4 to 7 total carbon atoms;
- X and Y are halo or lower alkyl;
- and
- x is 1 to 4.
A compound of the formula:
- ##STR10## wherein:
- R is --COOH;
- R.sup.7 alkyl, branched or unbranched, containing from 1 to 5 carbon atoms;
- and
- x is 1or 2.
A compound of claim 6, which is the sodium salt.
Dependencies are inferred from the claim text.