Process for recovery and purification of L-phenylalanine
AssigneeSynthetech, Inc.
InventorsDavid L. Evans, Roberta L. Thimmig, Robert C. Koltz
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Abstract
This invention concerns a process for the recovery and purification of L-phenylalanine from a reaction mixture containing L-phenylalanine and contaminants.
Claims18
A process for the recovery and purification of L-phenylalanine from an aqueous mixture containing L-phenylalanine and at least one contaminant said process comprising evaporating water to provide a sludge having a solid phase and a liquid phase, adding sufficient lower alkyl alcohol to dissolve substantially all of the contaminant cooling said sludge to a final temperature to increase formation of solid L-phenylalanine at a pH of at least 7.0, and separating said solid L-phenylalanine from said liquid phase
A process for the recovery and purification of L-phenylalanine from an aqueous mixture comprising L-phenylalanine, ammonium ions and an L-phenylalanine precursor said process comprising:
- (a) evaporating sufficient water to provide a sludge having a solid phase and a liquid phase;
- (b) adding an amount of a lower alkyl alcohol to said sludge to dissolve substantially all of said L-phenylalanine precursor and form a slurry;
- (c) cooling said slurry to a final temperature to provide solid L-phenylalanine while maintaining substantially all of said precursor in said liquid phase;
- (d) maintaining a pH of said slurry of at least 7.0;
- and
- (e) separating solid L-phenylalanine from said liquid phase.
Dependencies are inferred from the claim text.