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US 4,731,444 AGranted
Bicyclic lactams as antihypertensives
AssigneeMerck & Co., Inc.
InventorsWilliam H. Parsons, Matthew J. Wyvratt, Jr.
Life of this patent
Estimating the term…
Abstract
There are disclosed bicyclic lactams and derivatives thereof which are useful as converting enzyme inhibitors and as antihypertensives.
Claims1
A compound which is a member of the group:
- 6(S)-[1(S)-(benzyloxycarbonyl-3-phenylpropyl)amino]octahydro-5-oxo-9a(R)-th iazolo[3,2-a]azepine-3-(R)[2-diazo-1-oxoethane];
- 6(S)-[1(S)-(ethoxycarbonyl-3-phenylpropyl)amino]octahydro-5-oxo-9a(R)-thiaz olo[3,2-a]azepine-3-(R)[2-diazo-1-oxoethane];
- 6(S)-[1(S)-(benzyloxycarbonyl-3-phenylpropyl)amino]octahydro-5-oxo-9a(R)-th iazolo[3,2-a]azepine-3-(R)[2-hydroxy-1-oxoethane];
- 6(S)-[1(S)-(ethoxycarbonyl-3-phenylpropyl)amino]octahydro-5-oxo-9a(R)-thiaz olo[3,2-a]azepine-3-(R)[2-hydroxy-1-oxoethane];
- and,
- 6(S)-[1(S)-(carboxy-3-phenylpropyl)amino]octahydro-5-oxo-9a(R)-thiazolo[3,2 -a]azepine-3-(R)[2-hydroxy-1-oxoethane].
3 more elements
Dependencies are inferred from the claim text.