7-acylamino-3-vinylcephalosporanic acid derivatives
AssigneeFujisawa Pharmaceutical Co., Ltd.
InventorsTakao Takaya, Hisashi Takasugi, Takashi Masugi, Hideaki Yamanaka, Kohji Kawabata
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Abstract
The invention relates to novel intermediates for the preparation of antimicrobial compounds, the intermediate being a compound of the formula: ##STR1## in which R.sup.2 is carboxy or a protected carboxy group, R.sup.8 is 2-hydroxyphenyl and Z is a group of the formula: --CH.dbd.CH.sub.2, --CH.sub.2 --X.sup.2, --CH.sub.2 P.sup.+ (R.sup.7).sub.3.X.sup.3-, --CH.dbd.P(R.sup.7).sub.3 OR--CH.sub.2 OH, wherein X.sup.2 and X.sup.3 are each halogen and R.sup.7 is selected from the group consisting of phenyl, tolyl, xylyl and naphthyl, or a salt thereof.
Claims4
A compound of the formula:
- ##STR30## in which R.sup.2 is carboxy or a protected carboxy group,
- R.sup.8 is 2-hydroxyphenyl and
- Z is a group of the formula:
- --CH.dbd.CH.sub.2, --CH.sub.2 --X.sup.2, --CH.sub.2 p.sup.+ (R.sup.7).sub.3.X.sup.3 --, --CH.dbd.P(R.sup.7).sub.3 or --CH.sub.2 OH,
- wherein X.sup.2 and X.sup.3 are each halogen and R.sup.7 is selected from the group consisting of phenyl, tolyl, xylyl and naphthyl, or a salt thereof.
A compound of the formula:
- ##STR31## in which R.sup.2 is carboxy or a protected carboxy group, or a salt thereof.
A compound of the formula:
- ##STR32## in which R.sup.2 is carboxy or a protected carboxy group, or a salt thereof.
A compound of the formula:
- ##STR33## in which R.sup.2 is carboxy or a protected carboxy group and X.sup.2 is halogen, or a salt thereof.
Dependencies are inferred from the claim text.