Inorganic-organic compound substances for biomedical purposes

A method of producing inorganic-organic compound substances useful for biomedical purposes, comprising

• treating an inorganic initial material with 30 to 50% H.sub.3 PO.sub.4 for 1 to 24 hours at 25.degree. to 130.degree. C., said inorganic initial material being selected from the group consisting of a biocompatible silicate glass, a silicate glass ceramic or mixtures thereof having a composition by weight % of
• ______________________________________ SiO.sub.2 = 34-60 Al.sub.2 O.sub.3 = 21-36 MgO = 8-17 R.sub.2 O = 5-12 F.sup.- = 1-7 ______________________________________
• wherein R.sub.2 O represents the sum of 0-8 weight-% Na.sub.2 O and 0-6 weight-% K.sub.2 O,
• a bioactive phosphosilicate glass, a phosphosilicate glass ceramic (A) or mixtures thereof having a composition by weight % of
• ______________________________________ SiO.sub.2 = 19-52 Al.sub.2 O.sub.3 = 12-23 MgO 5-15 R.sub.2 O = 3-10 CaO = 9-30 P.sub.2 O.sub.5 4-24 F.sup.- 0.5-7 ______________________________________
• wherein R.sub.2 O represents the sum of 0-8 weight-% Na.sub.2 O and 0-8 weight-% K.sub.2 O,
• a bioactive phosphosilicate glass, a phosphosilicate glass ceramic (B) or mixtures thereof having a composition by weight % of
• ______________________________________ SiO.sub.2 = 18-63 MgO = 10-35 K.sub.2 O = 3-10 F.sup.- = 4-9 CaO = 1-30 P.sub.2 O.sub.5 = 1-30 ______________________________________
• a bioactive phosphate glass, a phosphate glass ceramic or mixtures thereof having a composition by weight % of
• ______________________________________ P.sub.2 O.sub.5 = 43-58 Al.sub.2 O.sub.3 = 3-21 CaO = 8-26 R.sub.2 O = 10-25 ______________________________________
• wherein R.sub.2 O can contain up to 25 weight-% Na.sub.2 O and up to 18 weight-% K.sub.2 O,
• a sintered ceramic comprising tricalcium phosphate, apatite and mixtures thereof;
• mixing 30 to 80 weight-% of said treated inorganic initial material with 20 to 70 weight-% of an organic initial material comprising a biocompatible, monomer-free, epoxidized polymeric hydrocarbon composed only of the elements C, H, O having an average molecular weight Mn of 2,000 to 6,000 and an epoxy equivalence EEW of 50 to 500 g, at a temperature of 45.degree. C. or less, to form a final reacted and chemically bonded inorganic-organic material resembling bone or cartilage suitable for endoprostheses, bone defect substitutions and body cartilage replacements, whereby said treatment with H.sub.3 PO.sub.4 facilitates said chemical bonding.

A method for producing inorganic-organic compound substances useful for biomedical purposes, comprising

• treating an inorganic initial material with 30 to 50% H.sub.3 PO.sub.4 for 1 to 24 hours at 25.degree. to 130.degree. C., said inorganic initial material being selected from the group consisting of a biocompatible silicate glass, a silicate glass ceramic or mixtures thereof having a composition by weight % of
• ______________________________________ SiO.sub.2 = 34-60 Al.sub.2 O.sub.3 = 21-36 MgO = 8-17 R.sub.2 O = 5-12 F.sup.- = 1-7 ______________________________________
• wherein R.sub.2 O represents the sum of 0-8 weight-% Na.sub.2 O and 0-6 weight-% K.sub.2 O,
• a bioactive phosphosilicate glass, a phosphosilicate glass ceramic (A) or mixtures thereof having a composition by weight % of
• ______________________________________ SiO.sub.2 = 19-52 Al.sub.2 O.sub.3 = 12-23 MgO 5-15 R.sub.2 O = 3-10 CaO = 9-30 P.sub.2 O.sub.5 4-24 F.sup.- 0.5-7 ______________________________________
• wherein R.sub.2 O represents the sum of 0-8 weight-% Na.sub.2 O and 0-8 weight-% K.sub.2 O,
• a bioactive phosphosilicate glass, a phosphosilicate glass ceramic (B) or mixtures thereof having a composition by weight % of
• ______________________________________ SiO.sub.2 = 18-63 MgO = 10-35 K.sub.2 O = 3-10 F.sup.- = 4-9 CaO = 1-30 P.sub.2 O.sub.5 = 1-30 ______________________________________
• a bioactive phosphate glass, a phosphate glass ceramic or mixtures thereof having a composition by weight % of
• ______________________________________ P.sub.2 O.sub.5 = 43-58 Al.sub.2 O.sub.3 = 3-21 CaO = 8-26 R.sub.2 O = 10-25 ______________________________________
• wherein R.sub.2 O can contain up to 25 weight-% Na.sub.2 O and up to 18 weight-% K.sub.2 O,
• a sintered ceramic comprising tricalcium phosphate, apatite and mixtures thereof;
• mixing 30 to 80 weight-% of said inorganic initial material with 20 to 70 weight-% of an organic initial material comprising a biocompatible, monomer-free, epoxidized polymeric hydrocarbon composed only of the elements C, H, O having an average molecular weight Mn of 2,000 to 6,000 and an epoxy equivalence EEW of 50 to 500 g, to form a reacted and chemically bonded inorganic-organic material, whereby said treatment with H.sub.3 PO.sub.4 facilitates said chemical bonding;
• and
• hardening said reacted inorganic-organic material to a particular shape at 25.degree. to 100.degree. C. to attain an implant material having long-term stability and various bioactive or biocompatible characteristics.

A method of producing inorganic-organic compound substances useful for biomedical purposes, comprising treating an inorganic initial material with 50% H.sub.3 PO.sub.4 for 12 hours at 110.degree. C., said inorganic initial material being selected from the group consisting of a biocompatible silicate glass, a silicate glass ceramic or mixtures thereof having a composition by weight % of

• ______________________________________ SiO.sub.2 = 34-60 Al.sub.2 O.sub.3 = 21-36 MgO = 8-17 R.sub.2 O = 5-12 F.sup.- = 1-7 ______________________________________
• wherein R.sub.2 O represents the sum of 0-8 weight-% Na.sub.2 O and 0-6 weight-% K.sub.2 O,
• a bioactive phosphosilicate glass, a phosphosilicate glass ceramic (A) or mixtures thereof having a composition by weight % of
• ______________________________________ SiO.sub.2 = 19-52 Al.sub.2 O.sub.3 = 12-23 MgO 5-15 R.sub.2 O = 3-10 CaO = 9-30 P.sub.2 O.sub.5 4-24 F.sup.- 0.5-7 ______________________________________
• wherein R.sub.2 O represents the sum of 0-8 weight-% Na.sub.2 O and 0-8 weight-% K.sub.2 O,
• a bioactive phosphosilicate glass, a phosphosilicate glass ceramic (B) or mixtures thereof having a composition by weight % of
• ______________________________________ SiO.sub.2 = 18-63 MgO = 10-35 K.sub.2 O = 3-10 F.sup.- = 4-9 CaO = 1-30 P.sub.2 O.sub.5 = 1-30 ______________________________________
• a bioactive phosphate glass, a phosphate glass ceramic or mixtures thereof having a composition by weight % of
• ______________________________________ P.sub.2 O.sub.5 = 43-58 Al.sub.2 O.sub.3 = 3-21 CaO = 8-26 R.sub.2 O = 10-25 ______________________________________
• wherein R.sub.2 O can contain up to 25 weight-% Na.sub.2 O and up to 18 weight-% K.sub.2 O,
• a sintered ceramic comprising tricalcium phosphate, apatite and mixtures thereof;
• mixing 30 to 80 weight-% of said inorganic initial material with 20 to 70 weight-% of an organic initial material comprising a biocompatible, monomer-free, epoxidized polymeric hydrocarbon composed only of the elements C, H, O having an average molecular weight Mn of 2,000 to 6,000 and an epoxy equivalence EEW of 50 to 500 g, to form a reacted and chemically bonded inorganic-organic material hardening to within 80% of final hardness within 20 minutes after mixing suitable for use as a tooth filling material and tooth structure material, whereby said treatment with H.sub.3 PO.sub.4 facilitates said chemical bonding.