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AssigneeBiogal Gyogyszergyar
InventorsIstvan Erczi, Jeno Marosfalvi, Gyorgy Rabloczky, Andras Varro, Maria Kuhar nee Kurthy, Istvan Elekes, Laszlo Szatmary, Laszlo Jaszlits
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The invention relates to new aminoguanidine derivatives of the general formula (I), ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 each represent hydrogen or halogen atom, C.sub.1-4 alkyl, nitro, trifluoromethyl or C.sub.1-4 alkoxy group, R.sup.4 and R.sup.5 represent a C.sub.1-4 alkyl group, furthermore NR.sup.4 R.sup.5 may form a 5 to 7 membered saturated heterocyclic group containing either one or two nitrogen atoms or a nitrogen and an oxygen atom and being optionally substituted by one or two methyl, hydroxymethyl or hydroxyethyl groups, R.sup.6 and R.sup.7 each represent a hydrogen atom, normal or branched C.sub.1-4 alkyl or C.sub.2-4 alkenyl group, and to their pharmaceutically acceptable acid addition salts as well as to a process for the preparation thereof. The new compounds of the invention possess valuable antiarrhythmic activity and are devoid of the undesired circulatory side effects of the known antiarrhythmic compounds.
An aminoguanidine derivative of the formula (I), ##STR35## wherein R.sup.1, R.sup.2 and R.sup.3 each represent hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, nitro, trifluoromethyl or C.sub.1 -C.sub.4 alkoxy,
1-(2-Methyl-phenyl)-4,4-dimethyl-aminoguanidine hydrochloride.
1-(2,6-Dichlorophenyl)-4,4-dimethyl-aminoguanidine hydrochloride.
1-(2,6-Dimethyl-phenyl)-4,4-dimethyl-aminoguanidine hydrochloride.
A pharmaceutical composition having antiarrhythmic activity containing as active ingredient an effective amount of at least one compound of the formula (I) ##STR36## wherein R.sup.1, R.sup.2 and R.sup.3 each represent hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, nitro, trifluoromethyl or C.sub.1 -C.sub.4 alkoxy,
Dependencies are inferred from the claim text.