Lipoxygenase inhibitory phenylalkanohydroxamic acids
AssigneeBristol-Myers Company
InventorsFred C. Zusi, Suresh A. Marathe, Kenneth M. Tramposch
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Abstract
Compounds of the formula ##STR1## where n=6-11 and M is hydrogen or a pharmaceutically acceptable cation are potent inhibitors of 5-lipoxygenase.
Claims20
A compound of the formula ##STR34## wherein n is an integer from six to eleven and M is hydrogen or a pharmaceutically acceptable cation.
The compound having the formula ##STR35##
The compound having the formula ##STR36##
The compound having the formula ##STR37##
A method of inhibiting 5-lipoxygenase activity in a mammalian host in need of such treatment which comprises administering to said host an amount of a compound of the formula ##STR38## wherein n is an integer from six to eleven and M is hydrogen or a pharmaceutically acceptable cation in an amount effective to inhibit 5-lipoxygenase activity in the host.
A pharmaceutically composition in unit dosage form for the inhibition of 5-lipoxygenase activity in a mammalian host, comprising a 5-lipoxygenase-inhibiting effective amount of a compound of the formula ##STR41## wherein n is an integer from six to eleven and M is hydrogen or a pharmaceutically acceptable cation and a pharmaceutically acceptable carrier.
A method of preventing or treating inflammation in a mammalian host which comprises administering to a host in need of such treatment a therapeutically effective amount of a compound of the formula ##STR44## wherein n is an integer from six to eleven and M is hydrogen or a pharmaceutically acceptable cation
A pharmaceutical composition for preventing or treating inflammation in mammals, which composition comprises a compound of the formula ##STR47## wherein n is an integer from six to eleven and M is hydrogen or a pharmaceutically acceptable cation in admixture with a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.