2-(-(2,2,5,5-tetramethyl-3-pyrrolin-3-carbonyl))-amino derivatives
AssigneeAlkaloida Vegyeszeti Gyar
InventorsKalman Hideg, Olga H. Hankovszky, Laszlo Frank, Ilona Bodi, Jozsef Csak
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AssigneeAlkaloida Vegyeszeti Gyar
InventorsKalman Hideg, Olga H. Hankovszky, Laszlo Frank, Ilona Bodi, Jozsef Csak
Estimating the term…
Compounds are disclosed of the formula (I) ##STR1## wherein A.sup.1 is a valence bond or a C.sub.1 to C.sub.5 straight or branched chain alkylene group unsubstituted or substituted by hydroxy or aminocarbonyl; B is a valence bond or a double bond; R.sup.3 is hydrogen or C.sub.1 to C.sub.4 alkyl; R.sup.2 is a phenyl or phenoxy group unsubstituted or substituted by one or two C.sub.1 to C.sub.4 alkyl groups, C.sub.1 to C.sub.4 alkoxy groups, or halo substituents; or R.sup.2 is an amino group, a diphenylmethyl group, or an R.sup.4 --NH--CO-- group in which R.sup.4 is 2,6-dimethyl-phenyl; or a pharmaceutically acceptable acid addition salt thereof. The compounds possess anti-arrhythmic activity and exert little or no hypotensive side effects.
A compound of the Formula (IA) ##STR51## wherein A.sup.1 is a C.sub.1 to C.sub.5 straight or branched chain alkylene group;
A compound of the Formula (IB) ##STR52## wherein A.sup.1 is a C.sub.1 to C.sub.5 straight or branched chain alkylene group;
A compound of the Formula (IC) ##STR53## wherein B is a valence bond or a double bond;
A compound selected from the group consisting of:
A compound of the Formula (ID) ##STR54## wherein A.sup.1 is a C.sub.1 to C.sub.5 straight or branched chain alkylene group;
Dependencies are inferred from the claim text.