Certain 5-acyl-1,2-dihydro-2-oxo-3-pyridinecarbonitriles which are useful as cardiotonic agents
AssigneeMerrell Dow Pharmaceuticals Inc.
InventorsWinton D. Jones, Richard A. Schnettler, Richard C. Dage
Life of this patent
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Abstract
Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.
Claims10
A compound of the formula ##STR5## or a pharmaceutically acceptable salt thereof, wherein R.sub.3 is --C.tbd.N,
- R.sub.4 is hydrogen or lower alkyl,
- R.sub.5 is phenyl, X-substituted phenyl, thienyl, furyl, pyrrolyl, and X is lower alkyl, lower alkoxy, lower alkyl thio, halogen, nitro, lower alkanoyl, alkoxy carbonyl, carboxy, cyano, NH.sub.2 CONH.sub.2, amindino, imidazol-2-yl, or CF.sub.3, and
- R.sub.6 is hydrogen, methyl or ethyl.
A method of treating cardiac failure in a patient in need thereof which comprises administering to said patient a cardiotonically effective amount of a compound of the formula ##STR6## or a pharmaceutically acceptable salt thereof, wherein R.sub.3 is --C.tbd.N,
- R.sub.4 is hydrogen or lower alkyl,
- R.sub.5 is pheny, X-substituted phenyl, thienyl, furyl, pyrrolyl, and X is lower alkyl, lower alkoxy, lower alkyl thio, halogen, nitro, lower alkanoyl, alkoxy carbonyl, carboxy, cyano, NH.sub.2, CONH.sub.2, amidino, imidazol-2-yl, or CF.sub.3, and
- R.sub.6 is hydrogen, methyl or ethyl.
Dependencies are inferred from the claim text.