Alkeneamidocephalosporin esters
AssigneeShionogi & Co., Ltd.
InventorsYoshio Hamashima, Koji Ishikura, Kyoji Minami, Tadatoshi Kubota, Tadashi Yoshida
Life of this patent
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Abstract
An oral antibacterial, 7beta-[(Z)-2-(2-aminothiazol-4-yl)-2-alkenoylamino]-3-cephem-4-carboxylic acid pharmaceutically acceptable ester represented by the following formula: ##STR1## (wherein R is amino or protected amino, R.sup.1 is straight, branched, or cyclic alkyl optionally substituted by alkoxy, R.sup.2 is hydrogen or a 3-substitutent of cephalosporins, R.sup.3 is a pharmaceutically acceptable ester group, and X is sulfur or sulfinyl).
Claims17
A 7.beta.-[2-(2-amino-4-thiazolyl)alkenoylamino]-3-cephem-4-carboxylic acid pharmaceutically acceptable ester represented by the following formula:
- ##STR9## wherein R is amino, X is sulfur, and
- R.sup.1 is ethyl;
- R.sup.2 is CH.sub.2 OCH.sub.2 CH.dbd.CH.sub.2 ;
- and R.sup.3 is pivaloyloxymethyl;
- R.sup.1 is ethyl;
- R.sup.2 is CH.sub.2 OCH.sub.2 CH.sub.2 F;
- and R.sup.3 is pivaloyloxymethyl;
- R.sup.1 is ethyl;
- R.sup.2 is CH.sub.2 OMe;
- and R.sup.3 is pivaloyloxymethyl;
- R.sup.1 is ethyl;
- R.sup.2 is CH.sub.2 OCH(Me).sub.2 ;
- and R.sup.3 is pivaloyloxymethyl;
- R.sup.1 is ethyl;
- R.sup.2 is H;
- and R.sup.3 is pivaloyloxymethyl;
- R.sup.1 is methyl;
- R.sup.2 is CH.sub.2 OCONH.sub.2 ;
- and R.sup.3 is pivaloyloxymethyl;
- R.sup.1 is ethyl;
- R.sup.2 is CH.sub.2 OCONH.sub.2 ;
- and R.sup.3 is pivaloyloxymethyl;
- R.sup.1 is ethyl;
- R.sup.2 is H;
- and R.sup.3 is 1-ethoxycarbonyloxyethyl;
- R.sup.1 is ethyl;
- R.sup.2 is H;
- and R.sup.3 is pivaloyloxyethyl;
- R.sup.1 is ethyl;
- R.sup.2 is H;
- and R.sup.3 is acetoxyethyl;
- R.sup.1 is ethyl;
- R.sup.2 is H;
- and R.sup.3 is acetoxymethyl;
- R.sup.1 is methyl;
- R.sup.2 is H;
- and R.sup.3 is pivaloyloxymethyl;
- R.sup.1 is ethyl;
- R.sup.2 is CH.sub.2 OCONH.sub.2 ;
- and R.sup.3 is acetoxyethyl;
- R.sup.1 is ethyl;
- R.sup.2 is CH.sub.2 OCONH.sub.2 and R.sup.3 is 1-ethoxycarbonyloxyethyl;
- or
- R.sup.1 is cycloproplymethyl;
- R.sup.2 is H;
- and R.sup.3 is pivaloyloxymethyl.
Dependencies are inferred from the claim text.