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US 4,731,244 AGranted
Monoclonal antibody therapy
AssigneeOrtho Pharmaceutical Corporation
InventorsMary A. Talle, Walter Newman, Patricia E. Rao, Gideon Goldstein
Life of this patent
Estimating the term…
Abstract
A method of seriatim administration to a patient of a plurality of ligands, each of which contains an antigen combining site of a monoclonal antibody of distinct idiotype, is disclosed. This method is useful for therapeutic as well as diagnostic purposes.
Claims16
A method for prolonging the time period a patient can be effectively subjected to therapeutic monoclonal antibody treatment, comprising:
- (a) administering to said patient an effective amount of a first monoclonal antibody, or an antigen binding fragment thereof, until the patient produces a detectable amount of an anti-idiotype antibody against said first antibody or fragment thereof;
- and
- (b) thereafter administering to said patient an effective amount of a second monoclonal antibody, or an antigen binding fragment thereof, wherein said second antibody or fragment is idiotypically distinct from said first antibody or fragment but functionally equivalent to said first antibody or fragment in binding to the same antigen.
A method for treating or ameliorating an acute or chronic allograft rejection episode in a patient. comprising:
- (a) administering to said patient a first monoclonal antibody, or an antigen binding fragment thereof, which includes an antigen binding site for the T3 antigen on human T cells in an amount effective to prevent or amieliorate an allograft rejection episode, said administration continuing unitl the patient produces a detectable amount of an anti-idiotype antobody against said first antibody or fragment thereof;
- and
- (b) thereafter administering to said patient an effective amount of a second monoclonal antibody, or an antigen binding fragment thereof, which includes an antigen binding site for the T3 antigen on human T cells, but is idiotypically distinct from said first antibody fragment.
Dependencies are inferred from the claim text.