Percutaneous pharmaceuticals preparation for external use
AssigneeTakeda Chemical Industries, Ltd.
InventorsMasayuki Yamada, Yoshiaki Uda
Life of this patent
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Abstract
A percutaneous pharmaceutical preparation for external use containing N-ethoxycarbonyl-3-morpholinosydnonimine (molsidomine) and an absorption promoter selected from the group consisting of aliphatic monoalcohols of 10 to 22 carbon atoms, aliphatic monoamides of 8 to 18 carbon atoms and aliphatic monoamines of 10 to 16 carbon atoms gives a high blood concentration of molsidomine over a long time period when applied onto the human skin.
Claims5
A percutanneous pharmaceutical preparation for external application which comprises
- (a) N-ethoxycarbonyl-3-morpholinosydnonimine;
- and
- (b) at least 0.01 weight part of an absorption promoter per weight part of (a) which promoter is an aliphatic monocarboxylic acid of 5 to 30 carbons.
A percutaneous pharmaceutical drug delivery system which comprises a support material having adhered or deposited thereon a preparation for external application which comprises
- (a) N-ethoxycarbonyl-3-morpholinosydnonimine;
- and
- (b) at least 0.01 weight part of an absorption propmoter per weight part of (a) which promoter is an aliphatic monocarboxylic acid of 5 to 30 carbons.
A method of percutaneously administering a vasodilator effect to a patient which comprises the percutaneous administration of N-ethoxycarbonyl-3-morpholinosydnonimine as 0.01 weight part absorption promoter per part of said vasodilator, said absorption promoter being an aliphatic monocarboxylic acid of 5 to 30 carbons.
Dependencies are inferred from the claim text.