Immune response to virus induced by anti-idiotype antibodies
AssigneeThe Wistar Institute
InventorsKevin J. Reagan, Tadeusz J. Wiktor, Hilary Koprowski
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Abstract
A method of inducing an immunological response in a host to a virus is provided employing anti-idiotype antibodies that present an internal image of a viral antigen to the host. Anti-idiotype antibodies and the cell lines that produce such antibodies are also provided.
Claims13
A method of inducing an immunological response to a rabies virus comprising:
- (a) providing an anti-idiotype antibody, an epitope identified by said anti-idiotype antibody being the parotope of an anti-rabies virus antibody;
- and
- (b) stimulating in a mammal the production of anti(anti-idiotype) antibodies that identify an epitope on a rabies virus particle by administering said anti-idiotype antibody to said mammel.
Polyclonal anti-idiotype antibodies, the epitope identified by said anti-idiotype antibodies being the parotope of an anti-rabies virus antibody, substantially free of anti-isotype antibodies.
An immortal B lymphocyte that produces an anti-idiotype antibody, the epitope identified by said anti-idiotype antibody being the parotope of an anti-rabies virus antibody, wherein said B lymphocyte has been immortalized by fusion with a malignant lymphocyte to produce a hybridoma.
Dependencies are inferred from the claim text.