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US 4,730,082 AGranted
Process for the preparation of methyltrifluoroacetate
AssigneeRhone-Poulenc Specialties Chimiques
InventorLouis Amiet
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Abstract
A process for the preparation of methyltrifluoroacetate. Trifluoroacetic acid is contacted with an excess of methanol and distilled to form a methyltrifluoroacetate/methanol azeotrope. The azeotrope is contacted with trifluoroacetic acid in the presence of a catalytic quantity of a strong acid followed by distillation to obtain methyltrifluoroacetate. The methyltrifluoroacetate can be used as a synthesis intermediate in the pharmaceutical industry.
Claims14
A process for the preparation of methyltrifluoroacetate comprising the steps of:
- (a) containing trifluoroacetic acid with an excess of methanol;
- (b) distilling the trifluoroacetic acid and methanol to form a methyltrifluoroacetate/methanol azeotrope;
- (c) contacting the azeotrope with trifluoroacetic acid in the presence of a catalytic quantity of a strong acid to form a mixture;
- and
- (d) distilling the mixture to obtain methyltrifluoroacetate and a residue.
2 more elements
Dependencies are inferred from the claim text.