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US 4,730,065 AGranted
15-deoxy-16-hydroxy-16-substituted prostanoic acids and congeners
AssigneeAmerican Cyanamid Company
InventorsMiddleton B. Floyd, Jr., Martin J. Weiss, Charles V. Grudzinskas, Sow-Mei L. Chen
Life of this patent
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Abstract
This disclosure describes novel 15-deoxy-16-hydroxy-16-substituted prostanoic acids and congeners thereof having utility as bronchodilators as hypotensive agents, and as agents for the control of excessive gastric secretion.
Claims14
A compound of the formula:
- ##STR26## wherein R.sub.1 is an alkyl or alkenylmethyl group having 3 to 7 carbon atoms or said alkyl or alkenylmethyl group is substituted with one or two alkyl groups having one to three carbon atoms and wherein R.sub.2 is a substituent selected from the group consisting of vinyl and cyclopropyl.
A compound of the formula:
- ##STR27## wherein R is a moiety selected from the group consisting of MgBr and ##STR28## R.sub.1 is an alkyl or alkenylmethyl group of 3 to 7 carbon atoms or said alkyl or alkenylmethyl group substituted with one or two alkyl groups of one to three carbon atoms, and wherein R.sub.2 is vinyl or cyclopropyl.
A compound of the formula:
- ##STR29## wherein W is iodine or tri-n-butylstannyl, R.sub.5 is vinyl or cyclopropyl, R.sub.6 is hydrogen or triloweralkylsilyl and R.sub.1 is an alkyl or alkenylmethyl group having 3 to 7 carbon atoms, or said alkyl or alkenylmethyl group substituted with one or two alkyl groups of one to three carbon atoms.
Dependencies are inferred from the claim text.